Pemphigus Vulgaris histology picture with annotations.

Pemphigus Vulgaris: Diagnosis, Treatment, and Prognosis

What is Pemphigus Vulgaris? Pemphigus Vulgaris is a chronic mucocutaneous vesicular bullous condition, is autoimmune, and it's caused by antibodies that target the attachments between cells. These attachments, called desmosomes, are made by little proteins that make up the attachment between epithelial cells. In the condition, the epithelium just falls apart. Splitting and separation (acantholysis) of the epithelium occurs above the basal layer. Pemphigus Vulgaris Differentials Here are two clinical pictures of ...
Read More
BruceBlaus [CC BY-SA 4.0 (], from Wikimedia Commons

Relieving Migraine Headache Pain with Trigeminal Nerve Stimulation

If you suffer from migraine headaches, you are not alone. In fact, the National Institutes of Health reports that around 12 percent of the U.S. population gets them. Migraine headaches are recurring attacks of pain that people experience which range from moderate to severe, including pain throbs or pulses. Many things trigger migraine headaches, including anxiety, stress, exposure to light, and even a lack of sleep or food. Relieving Migraine Headache ...
Read More

What is the difference between a vesicle and an oral ulcer?

We are going to review the differences between vesicles and ulcerations, two types of lesions found in an oral cavity. If you look at this oral mucosa decision tree for oral lesions, many of these lesions are classified as vesiculobullous or vesicular ulcerative conditions. The Difference between a Vesicle and an Ulcer In order to explore the scope of ulcerative conditions in later articles, let’s start with the difference between a vesicle ...
Read More
Relieve chronic cluster headache pain with spenopalatine ganglion stimulation.

Chronic Cluster Headache Pain Relief: Promising Long-Term Treatment

For the many people who suffer from chronic cluster headache pain, they know all too well how debilitating it can be. Considered to be a very painful headache, it’s a pain that makes it difficult to continue normal activities. The good news is that there are promising new ways to treat and prevent cluster headaches. Sphenopalatine Ganglion Stimulation In the February 2018 issue of the Journal of Pain Research, scientists shared ...
Read More

Medication-Related Osteonecrosis of the Jaw: A Brief Overview

Antiresorptive drugs such as bisphosphonates (BP) and denosumab are primarily utilized in the treatment of osteoporosis and certain cancers in bone (e.g. multiple myeloma) or metastatic cancers to the bones (e.g. breast, prostate, colon, lung). Treating patients with a history of BP or denosumab therapy in the dental setting can have potentially serious complications, particularly bisphosphonate-related osteonecrosis of the jaw (BRONJ) or medication-related osteonecrosis of the jaw (MRONJ). Assessment of ...
Read More