Dry Mouth: Medications and their Effect on Saliva


By far, the most common cause of long standing dry mouth particularly in older adults is the use of xerogenic medications [30].

There are now projected to be over a thousand medications associated with subjective and/or objective oral dryness either by interfering with the production of saliva or the pathways responsible for saliva secretions [31], [57], [58], [59], [60].

Dr. Roseanne Mulligan, DDS, MS, Geriatric Dentistry Online Postgraduate Dental Degree Program, USC Dentistry
Dr. Roseanne Mulligan, DDS, MS, Geriatric Dentistry Online Postgraduate Dental Degree Program, USC Dentistry

Most commonly the inhibition is due to the impact of the drug on central and peripheral receptors resulting in anticholinergic activity against the M3 muscarinic receptors; the end result being reduced salivation [25], [35], [61].

Related reading: Geriatric Dentistry: Understanding the Role of Saliva

A review of oral side effects of 131 of the most frequently prescribed drugs in the USA in 1992 showed dry mouth or xerostomia to be the most common oral side effect (80.5%) followed by alteration in taste (47.5%) and stomatitis (33.95%) [55].

In a study by Thomson et al., 42.3% of the medications taken by institutionalized older adults presented xerogenic effects [62].

Drugs most commonly implicated with subjective and objective dry mouth are the medications with anticholinergic actions, sympathomimetic actions, such as tricyclic antidepressants, antipsychotics, atrophinic drugs to treat overactive bladder, decongestants, bronchodilators, anti-hypertensive drugs including beta-blockers and diuretics, anti-histamines, sedative hypnotics, opiates, and muscle relaxants [25], [31], [59], [60], [62].

Chemotherapeutic agents such as cytotoxic drugs and cytokines, retinoids, thyroid supplements, and anti-HIV medications are also known to cause dry mouth as the common adverse effect [55], [60].

Selective Drugs that May Give Rise to Dry Mouth

A complete and searchable list of drugs associated with dry mouth with the frequency of dry mouth reported by patients taking these drugs, is provided on the following website: www.drymouth.info [59].

These tables are a partial list of medications that have the potential to cause dry mouth [44], [45], [58], [59], [64], [65].

Medications that Cause Dry Mouth by Anticholinergic Action

Antidepressants: SSRI, SNRI
Venlafaxine, Duloxetine, Mirtazapine, Bupropion
AntihypertensiveMetoprolol, Timolol, Clonidine, Prazosin, Terazosin
Appetite Suppressants and CNS StimulantsPhentermine, Amphetamine/Dextroamphetamine
Decongestants and cold curesPseudoephedrine
BronchodilatorsAlbuterol, Formoterol
Skeletal muscle relaxants Cyclobenzaprine, Tizanidine
Antimigraine agentsZolmitriptan, Rizatriptan

Medications that Cause Dry Mouth by Sympathomematic Action

Opioids
Fentanyl, Tramadol, Oxycodone
Nonbenzodiazepine hypnoticsZolpidem, Eszopiclone, Zolpiclone
BenzodiazepineAlprazolam, Lorazepam, Diazepam, Triazolam, Temazepam
Drug of abuseMethamphetamine

Medications that Cause Dry Mouth by Synergistic Action

H2 Antagonists, proton pump inhibitorsOmeprazole
AntibioticsAmoxicillin, Tetracycline, Metronidazole
Antineoplastic/cytotoxic drugs Interferon Alpha, Fluorouracil, IL2
Anti-HIV drugsDidanosine, Protease inhibitors such as indinavir
SupplementsRetinoids

Other Medications that Cause Dry Mouth

General• Old age
• Female sex
• Dehydration
• Disability (cognitive and physical)
• Institutionalization
• Habits (mouth breathing, smoking, alcohol and drug abuse)
• Compromised masticatory function
Iatrogenic• Medications*
• Therapeutic irradiation*
• Chemotherapy/immunotherapy
• Chronic graft vs host disease
• Salivary duct ligation
• Liquid diet feeding
Salivary Gland Diseases and Disorders• Agenesis of the salivary glands (with or without ectodermal dysplasia)
• Sialoadenitis
• Sialolithiasis
Chronic Inflammatory
Autoimmune Diseases
• Sjogren’s syndrome*
• Other rheumatologic diseases; Rheumatoidarthritis, SLE, scleroderma, mixed connective tissue disease
• Sarcoidosis Amyloidosis
• Crohn’s disease, ulcerative colitis
Endocrine Diseases• Diabetes mellitus
• Hyper-and hypothyroidism
• Cushing’s syndrome
• Addison’s disease
Neurologic Diseases and Disorders• Stroke
• Parkinson’s disease
• Bell’s palsy
• Alzheimer’sdisease
Psychogenic Diseases and Conditions• Stress
• Anxiety and nervousness
• Depression
• Eating disorders (anorexia nervosa, bulimia)
Infections• HIV/AIDS
• HCV
• Tuberculosis
• Human T lymphotropicvirus (HTLV-1)
Other Diseases• Cysticfibrosis
• Hypertension
• Fibromyalgia
• Chronic fatigue syndrome
• Burning mouth syndrome
• Primary biliary cirrhosis
• Liver transplant candidates
• Renal diseases and Renal dialysis
• Anemia
• Atrophicgastritis
*Major causes of dry mouth

Medication Effect on Saliva in the Older Adult

The prevalence of dry mouth increases with increasing numbers of medications used for one or more conditions (polypharmacy) [25], [29], [30], [44], [62], [63].

The prevalence of the perceived symptoms of dry mouth among subjects aged 20–80 years was 17% in patients taking no medication, 33.5% in patients taking 3 medications and 67% with the use of more than or equal to 7 medications [30], [44].

In a study that focuses on only older adult patients (age > 65 years) with limited mobility, limited resources or complex health status, the prevalence jumps to 37% when taking 1 medication, 62% with 2 medications and reaches 78% when 3 medications were used [29].

Related reading: Dental Care for Geriatric Patients: Xerostomia in Elderly Populations

Age and medication seemed to play a more central role when there was objective evidence of hypo-salivation while female gender and psychological factors were more related to the subjective sensation of oral dryness. Clearly, the presence of medication is a more likely predictor of the risk of dry mouth than either age or gender [25].

When drug-associated symptoms of dry mouth occur, the timeline of the symptoms and the initiation of the medication are likely to be closely related [60].

Related reading: Geriatric Dental Care: Older Adults and Oral Conditions

Postgraduate Degrees in Geriatric Dentistry

Are you looking for improved ways to diagnose, treat, and manage the oral healthcare of older patients? Explore the Herman Ostrow School of Dentistry of USC’s online master’s and certificate program in Geriatric Dentistry.

About the Authors

The article, “Dry mouth: A critical topic for older adult patients,” was authored by Phuu Han, Piedad Suarez-Durall, and Roseann Mulligan, Director Geriatric Dentistry Master and Certificate programs at the Herman Ostrow School of Dentistry of USC, and was originally published by Elsevier in the Journal of Prosthodontic Research.

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